Magtein associated with improvements in cognition, brain age, and physiological stress markers, clinical trial finds

Magtein, a unique source of bioavailable magnesium, is associated with improvements in cognitive performance, memory, reaction time, brain cognitive age, and heart rate, a clinical trial has found.¹ 

Magtein, the patented proprietary form of magnesium L-threonate, is used in dietary supplements to support sleep, healthy brain aging, and cognitive vitality. It has been shown to work by effectively crossing the blood-brain barrier. 

In a new randomized, double-blind, placebo-controlled trial, 100 healthy adults (18–45 years) with self-reported dissatisfied sleep supplemented with 2g daily of Magtein or a placebo for six weeks.  

Cognitive performance was measured by the NIH Cognitive Toolbox, while a wearable sleep-tracking device (Oura Ring) provided data on physiological stress markers including heart rate (HR) and heart rate variability (HRV). Sleep quality was also measured through self-report questionnaires such as PROMIS Sleep, while reaction times and hand-eye co-ordination were assessed by a digital aim trainer.  

Participants in the Magtein demonstrated group demonstrated:  

• Improved overall cognitive performance

• Greater improvements in working and episodic memory

• A 7.5-year reduction in estimated brain cognitive aging

• Faster reaction times 

• Reduced resting heart rate and increased heart rate variability

• Improvement in PROMIS sleep-related impairment.

Magtein has been extensively studied for its ability to support brain magnesium levels and has demonstrated benefits for cognitive performance and sleep quality in human trials. The new research adds to this clinical foundation by further confirming these effects and expanding the understanding of its benefits.  

Dr. Jennifer Gu, SVP of R&D at Magtein, said, “While earlier studies have demonstrated that Magtein supports cognitive performance in older populations, this latest research confirms those benefits also extend to younger adults. It also highlights additional positive outcomes related to cognitive function, sleep-related measures, and physiological markers of neurological and heart health, including improved heart rate variability, which is demonstrated for the first time. Together, these findings build on a growing body of research supporting Magtein and further strengthen the scientific foundation behind its broad cognitive and neurological benefits.”

She added, “As we look ahead, additional ongoing and upcoming studies will continue to expand our understanding of Magtein and its benefits. The growing body of evidence supports its use in formulations designed to support healthy brain cognitive aging, stress resilience, and sleep.”  

The study was conducted by researchers at Clinical Research Australia, Perth. It is published in Frontiers in Nutrition: https://www.frontiersin.org/journals/nutrition/art​icles​/10.3​389/f​nut.2​025.1​72916​4/ful​l

¹ Lopresti AL, Smith SJ. The effects of magnesium L‑threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double‑blind, placebo‑controlled trial. Front Nutr. 2025;12:1729164. doi:10.3389/fnut.2025.1729164